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Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study

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成果类型:
期刊论文
作者:
Ba, Yuchen;Shen, Lele;Peng, Xiangning;Zhang, Yujin;Wang, Junwen
通讯作者:
Wang, JW
作者机构:
[Wang, Junwen; Zhang, Yujin; Ba, Yuchen; Peng, Xiangning; Wang, JW] Hunan Univ Chinese Med, Hosp 2, 233 Cai E North Rd, Changsha 410005, Hunan, Peoples R China.
[Shen, Lele] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.
通讯机构:
[Wang, JW ] H
Hunan Univ Chinese Med, Hosp 2, 233 Cai E North Rd, Changsha 410005, Hunan, Peoples R China.
语种:
英文
关键词:
derived antioxidants;diet;Mendelian randomization;non-scarring alopecia
期刊:
MEDICINE
ISSN:
1357-3039
年:
2024
卷:
103
期:
24
页码:
e38426
基金类别:
Innovation Project for Graduate Students of Hunan University of Chinese Medicine [2023CX21]; Hunan Provincial Natural Science Foundation [2022JJ30442]; Construction Project of National Advantageous Specialties in Traditional Chinese Medicine [2024-469]
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
第二中医临床医学院
摘要:
Previous observational studies revealed controversy about the effect of circulating antioxidants on risk of alopecia. In the present study, we investigated the causal relationships between diet-derived circulating antioxidants and 2 non-scarring alopecia using Mendelian randomization (MR). Instrumental variables for antioxidants (lycopene, retinol, ascorbate, beta-carotene, alpha-tocopherol, and gamma-tocopherol) were selected from published studies. Data for alopecia areata (AA) and androgenetic alopecia (AGA) was obtained from the FinnGen study project (R9 released in 2023), including 195 ca...

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