Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tian, Fengming;Yi, Jian;Liu, Yingfei;Chen, Bowei;Wang, Xiaoju;...

通讯作者：

Liu, BY

作者机构：

[Yi, Jian; Tian, Fengming; Liu, Baiyan; Wang, Xiaoju; Liu, Jian; Chen, Bowei; Ouyang, Yin; Long, Hongping; Liu, Yingfei] Hunan Univ Chinese Med, Affiliated Hosp 1, 95 Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.

[Yi, Jian; Liu, Baiyan; Liu, BY] Hunan Acad Chinese Med, 58 Lushan Rd, Changsha 410007, Hunan, Peoples R China.

[Yi, Jian; Tian, Fengming; Chen, Bowei; Ouyang, Yin; Liu, Yingfei] Hunan Univ Chinese Med, 300 Xueshi Rd, Changsha 410006, Hunan, Peoples R China.

[Tang, Yan] Yiyang Med Coll, 516 Yingbin Rd, Yiyang 413499, Hunan, Peoples R China.

通讯机构：

[Liu, BY ] H

Hunan Acad Chinese Med, 58 Lushan Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Angiogenesis;Buyang huanwu decoction;Cerebral infarction;Glycolysis;Traditional Chinese medicine

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2024

卷：

319

期：

Pt 3

页码：

117218

DOI：

10.1016/j.jep.2023.117218

基金类别：

Fundings This work was supported by the National Natural Science Foundation of China (No. 82074251), the Hunan Graduate Research Innovation Project (No. CX20220805), the Natural Science Foundation of Hunan Province (No.2022JJ30357).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Promoting the recovery of cerebral blood circulation after cerebral infarction (CI) is an important intervention. Buyang Huanwu decoction (BHD) is a classic prescription for treating CI that promotes angiogenesis. Cytoplasmic glycolysis ischaemic-region cells after CI may be highly activated to maintain metabolic activity under hypoxia. From the perspective of long-term maintenance of glycolytic metabolism in the ischaemic area after CI, it may be beneficial to promote angiogenesis and maintain glial cell activat...

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Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction

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