Triptolide (TP) can cause severe hepatotoxicity which limits its clinical application.Isoliquitigenin (ISL) has been reported to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclear transcription factor E2-related factor 2 (Nrf2) and hepatic transporters in TP-induced hepatotoxicity and the reversal effects of ISL on it. TP treatment caused cytotoxicity in human L02 hepatocytes and acute liver injury in ICR mice reflected by changes in liver indices, histopathology, serum biochemical indices, as well as the hepatic...
