期刊论文

中文

湖南中医药大学学报

1674-070X

2003

23

2

7-9

10.3969/j.issn.1674-070X.2003.02.003

湖南省教育厅资助项目 （A0 0 64 ）；

本校为第一机构

目的 观察土鳖虫提取液对家兔抗凝血作用的影响。方法 (1) 体内实验 给家兔灌胃土鳖虫提取液5d后，测定白陶土部分凝血酶时间（KPTT）、凝血酶原时间(PT)、凝血酶时间(TT)；(2) 体外实验 体外测定土鳖虫提取液对家兔血浆KPTT、PT、TT及抗凝血酶Ⅲ（AT-Ⅲ）的影响。结果 土鳖虫提取液在家兔体内、外均能使血浆KPTT、PT及TT延长，其作用随土鳖虫提取液浓度的增加而增强，抗凝活性不依赖于AT-Ⅲ。结论 土鳖虫提取液具有明显的抗凝作用，可能是对凝血酶发挥的直接作用。

Objective To experimentally investigate the anticoagulant effect of extract form Eupolyph age sinesis Waler (ESW) on rabbits. Methods Activated kaolin partial thrombop lastin time (KPTT), prothrombin time (PT) and thrombin time (TT) were assaied in vivo on the fifth day following fed extract solution to the animals,and Ant ithrombin Ⅲ (AT Ⅲ), KPTT, PT and TT were measured in vitro following ESW ex tract being added into the rabbit plasma. Results KPTT, PT and T T were shown prolonged significantly in the experiments in vitro and vivo. The eff...