Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms

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成果类型：

期刊论文

作者：

Song, Houpan;Xiong, Meng;Yu, Chang;Ren, Baoping;Zhong, Meiqi;...

通讯作者：

Zeng, MY;Cai, X;Peng, QH

作者机构：

[Zhou, Shunhua; Gao, Qing; Yu, Chang; Peng, Qinghua; Xiong, Meng; Zhong, Meiqi; Ren, Baoping; Wang, Xiaojuan; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Tradit Chinese Med Diagnost, Changsha, Hunan, Peoples R China.

[Zhou, Shunhua; Gao, Qing; Yu, Chang; Zeng, Meiyan; Xiong, Meng; Zhong, Meiqi; Ren, Baoping; Wang, Xiaojuan; Song, Houpan] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Ou, Chen; Peng, Qinghua; Lu, Jing] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Sch Int Educ, Changsha, Hunan, Peoples R China.

[Zeng, Meiyan; Zeng, MY] Hunan Univ Chinese Med, Coll Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Peng, QH ; Cai, X ; Zeng, MY ] H

Hunan Univ Chinese Med, Coll Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Int Educ, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Gastric ulcer;Huang-Qi-Jian-Zhong-Tang;Inflammation;NF-κB;Oxidative stress;STAT

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2024

卷：

319

期：

Pt 2

页码：

117264

DOI：

10.1016/j.jep.2023.117264

基金类别：

National Natural Science Foundation of China [82374429, 82004427]; Science and Technology Innovation Program of Hunan Province [2021RC3101]; Natural Science Foundation of Hunan Province [2023JJ30460, 2023JJ40474]; Guidance Project of Academician Liu Liang's Expert Workstation [22YS003]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

国际教育学院

摘要：

Ethnopharmacological relevance: Huang-Qi-Jian-Zhong-Tang (HQJZT) is a canonical traditional Chinese medicine (TCM) formula that has been widely used in both the prevention and treatment of gastrointestinal diseases, including gastric ulcer, duodenal ulcer, and chronic atrophic gastritis, in China. Aim of the study: In the present study, we investigated the gastroprotective potential of HQJZT in a rat model of indomethacin (IND)-induced gastric ulcer and explained the biochemical, cellular, and molecular mechanisms involved. Materials and methods: Observations were conducted at the macroscopic ...

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Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms

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