Downregulated ferroptosis-related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yao, Lei;Li, Juanni;Zhang, Xiaofang;Zhou, Lei;Hu, Kuan

通讯作者：

Kuan Hu

作者机构：

[Hu, Kuan; Yao, Lei] Cent South Univ, Xiangya Hosp, Dept Hepatobiliary Surg, Changsha 410008, Hunan, Peoples R China.

[Li, Juanni] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Peoples R China.

[Li, Juanni] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

[Zhang, Xiaofang] Hunan Univ Chinese Med, Ningxiang Peoples Hosp, Dept Burn, Changsha, Peoples R China.

[Zhang, Xiaofang] Hunan Univ Chinese Med, Ningxiang Peoples Hosp, Dept Plast, Changsha, Peoples R China.

通讯机构：

[Kuan Hu] D

Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, China

语种：

英文

关键词：

chemoresistance;ferroptosis;GBM;SQLE;TMZ

期刊：

CNS Neuroscience & Therapeutics

ISSN：

1755-5930

年：

2022

卷：

期：

页码：

2104-2115

DOI：

10.1111/cns.13945

基金类别：

National Natural Science Foundation of China [82102743, 82103300]; Outstanding Postdoctoral Innovative Talents Foundation [2021RC2022]; Youth Science Foundation of Xiangya Hospital [2020Q07]

机构署名：

本校为其他机构

摘要：

Chemoresistance in patients with glioblastoma multiforme (GBM) is a common reason hindering the success of treatment. Recently, ferroptosis has been reported to be associated with chemoresistance in different types of cancer, while the role of ferroptosis-related genes in GBM have not been fully elucidated. This study aimed to demonstrate the roles and mechanism of ferroptosis-related genes in chemoresistance and metastasis of GBM. First, two candidate genes, squalene epoxidase (SQLE) and FANCD2, were identified to be associated with ferroptosis-related chemoresistance in GBM from three temozo...

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Downregulated ferroptosis-related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma

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