期刊论文

中文

中国中西医结合耳鼻咽喉科杂志

1007-4856

2008

16

4

245-247

10.16542/j.cnki.issn.1007-4856.2008.04.008

国家自然科学基金（编号30271678）；

本校为第一机构

目的 观察二亚硝基哌嗪在正常状态和气虚状态大鼠鼻咽上皮细胞的诱癌效率差异以及黄芪、黄连复方有效成分的防护作用.方法 SD大鼠每日力竭游泳10min,连续30d以建立气虚状态模型,然后分组,每组动物10只.DNP皮下注射法诱癌,并应用黄芪,黄连复方有效成分进行干预.干预完成后200天,分别取各组动物鼻咽黏膜行常规病理组织学和超微病理观察.结果 力竭游泳联合DNP诱癌组动物中,鼻咽黏膜上皮细胞出现癌前病变例数(n1=8)显著多于单纯DNP诱癌组(n2=3,P＜0.05),而应用益气解毒中药干预后,该类动物鼻咽黏膜上皮细胞癌前病变例数显著降低(n3=3,p＜0.05).结论 气虚状态下,实验动物鼻咽黏膜上皮细胞对DNP诱癌效...

Objective To observe the differences in the occurring rates of induced precancerous lesion by DNP （N, N＇-dinitrosopiperazine） in nasopharyngeal epithelia among rats either at a normal physique status or at a Qi deficient one and to investigate the inhibitory effects of active components of milkvetch root （MR） and Compound Coptis Root Formula （CCRF） on the development of this kind of induced precancerous lesion. Methods Included in this experimental study were 50 rats, to prepare the physique model of Qi deficient status at first by a pro...