Silencing of lncRNA CRNDE attenuates nonsmall-cell lung cancer progression by mediating the miR-455-3p/HDAC2 axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Na;Chen, Xiao-Juan;Zeng, Yun-Hui;Zeng, Li-Ping;Hu, Ke;...

通讯作者：

Li-Jun Chen

作者机构：

[Li, Na] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China.

[Chen, Li-Jun; Li, Na; Hu, Ke; Zeng, Yun-Hui; Zeng, Li-Ping] Hunan Univ Med, Med Coll, 492 Southern Jinxi Rd, Huaihua 418000, Hunan, Peoples R China.

[Li, Na] Hunan Univ Med, Affiliated Hosp 1, Dept Pathol, Huaihua, Hunan, Peoples R China.

[Chen, Xiao-Juan] Hunan Maternal & Child Care Hosp, Dept Clin Lab, Changsha, Hunan, Peoples R China.

通讯机构：

[Li-Jun Chen] M

Medical College, Hunan University of Medicine, Huaihua, Hunan Province, China

语种：

英文

关键词：

CRNDE;HDAC2;miR-455-3p;nonsmall cell lung carcinoma

期刊：

The Kaohsiung Journal of Medical Sciences

ISSN：

1607-551X

年：

2022

卷：

期：

页码：

749-760

DOI：

10.1002/kjm2.12558

基金类别：

the College Students’ Innovation and Entrepreneurship Training Program of Hunan Province, Grant/Award Number: 2020-4260; the General Project of Hunan Provincial Education Department, Grant/Award Number: 18C1129; the Natural Science Foundation of Hunan Province, Grant/Award Number: 2019JJ50425

机构署名：

本校为第一机构

院系归属：

医学院

第二中医临床医学院

摘要：

Nonsmall-cell lung carcinoma (NSCLC) is one of the deadliest malignancies in the world. LncRNAs are confirmed to be involved in the progression of NSCLC. Meanwhile, lncRNA CRNDE is known to be upregulated in NSCLC; however, the mechanism by which CRNDE regulates the tumourigenesis of NSCLC remains unclear. To test the function of CRNDE in NSCLC, cell proliferation, invasion, and migration were investigated by colony formation and Transwell assays, respectively. qPCR and Western blotting were applied to test gene and protein levels. In addition, the relationship among CRNDE, miR-455-3p, and HDA...

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Silencing of lncRNA CRNDE attenuates nonsmall-cell lung cancer progression by mediating the miR-455-3p/HDAC2 axis

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