期刊论文、会议论文

中文

中华中医药杂志

1673-1727

2014

29

5

1490-1498

第五届全国中医药博士生学术论坛

第五届全国中医药博士生学术论坛论文集

2014-04-19

长沙

中华中医药学会<&wdkj&>《中华中医药杂志》<&wdkj&>北京岐黄中医药文化发展基金会

State Administration of Traditional Chinese Medicine’Pharmaceutical Botany’Key Subject(No.[2009]30);Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province(No.[2010]212);Key Subjects Construction Program during the’Twelfth Five-year’Plan Period of Hunan Province(No.[2011]76);Hunan Provincial Innovation Foundation for Postgraduate(No.CX2013B328)~~

本校为第一机构

目的:运用网络药理学技术,阐释分子-靶标-疾病之间的相互关系,并从基因、蛋白、信号通路等多网络层次上探讨肝复乐治疗肝细胞癌的药效物质与疗效机制。方法:文章从系统生物学角度出发,建立了一种基于计算机策略的集成方法,对肝复乐进行类药性预测、ADME(吸收、分布、代谢与排泄)预测、分子对接与多成分、多靶点、多途径的网络模型建立。结果:确定了与8个肝癌靶点相关的69种具有潜在活性的抗癌成分及治疗肝癌的基本

Objective： To illustrate interactions among moleculars, targets and diseases using network pharmacology and to explore the efficacy materials and mechanism of Ganfule （GFL） treating hepatocellular carcinoma （HCC） from gene, protein, signaling pathway and so on based on multi-network level. Methods： We constructed a computational systems approach that integrated druglikeness prescreening, ADME （absorption, distribution, metabolism and excretion） prediction, molecular docking and multi-components, multi-targets, multi-pathways networks co...