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Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

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成果类型:
期刊论文
作者:
强伟杰;陈颖;贺福元;肖美凤;蔡维艳;...
通讯作者:
Zhu, X.-X.
作者机构:
[李玉洁; 王娅杰; 戴逸飞; 杨庆; 陈颖; 蔡维艳; 朱晓新; 李琦; 翁小刚] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Anhui University of Chinese Medicine, Hefei, Anhui 230012, China
[肖美凤; 贺福元] College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208, China
[强伟杰] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China
通讯机构:
[Zhu, X.-X.] I
Institute of Chinese Materia Medica, China
语种:
中文
关键词:
远志散;网络药理学;有效成分-AD靶标网络;网络分析;痴呆
关键词(英文):
Yuan Zhi powder;Network pharmacology;Active ingredients–AD targets network;Network analysis;Dementia
期刊:
数字中医药(英文)
ISSN:
2096-479X
年:
2018
卷:
1
期:
1
页码:
90-101
基金类别:
We thank for the funding support from the Major new drug creation project (2017ZX09101002-002-008), National Natural Science Foundation of China (81403171) and Autonomous Program of China Academy of Chinese Medical Sciences (QZPT001 and 2014065).
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
目的 采用网络药理学技术预测远志散治疗老年痴呆的主要活性成分、潜在靶点及分子作用机制.方法 通过数据库及文献构建远志散的化学成分库,进行反向分子对接预测潜在靶点,构建成分-靶标网络;通过与AD的靶标网络进行映射、分析,获得"有效成分-AD靶标"网络;通过网络分析筛选出关键靶点;通过与已知文献报道的靶点进行对比,分析预测靶点的合理性.结果 远志散各味中药共有180种化学成分作用于AD靶标,其作用靶标包括三个关键靶标(环氧酶-2、毒蕈碱型乙酰胆碱受体M1、毒蕈碱型乙酰胆碱受体M2)及一个重要靶标(乙酰胆碱酯酶).可能通过调节乙酰胆碱受体活性及与β-淀粉样蛋白结合从而治疗阿兹海默症,其生物...
摘要(英文):
Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology. Methods A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures. Potential targets were predicted by reverse molecular docking, and then a component-target network was constructed. The target network of Alzheimer's disease (AD) was mapped and analyzed to obtain the “active ingredient-AD target” network. The key targets were scre...

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