Network Pharmacology-based Analysis on the Molecular Biological Mechanisms of Xin Hui Tong Formula in Coronary Heart Disease Treatment

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成果类型：

期刊论文

作者：

吴华英;张臣;王朝华;张世鹰;李静;...

通讯作者：

Huang Hui-Yong<&wdkj&>Li Liang

作者机构：

[Hua-Ying W.; Hui-Yong H.; Jing L.] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

[Chen Z.; Zhao-Hua W.] Department of Cardiology, The Hunan Brain Hospital, Changsha, Hunan 410007, China

[Feng L.] Center for Oral/Head & Neck Oncology Research, School of Dentistry, University of California, Los Angeles, CA 90095, United States

Department of Traditional Chinese Medicine, Luohu District People's Hospital, Shenzhen, Guangdong 518001, China

[Shi-Ying Z.] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Department of Traditional Chinese Medicine, Luohu District People's Hospital, Shenzhen, Guangdong 518001, China

通讯机构：

[Huang Hui-Yong; Li Liang] P

Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>Center for Oral/Head & Neck Oncology Research, School of Dentistry, University of California, Los Angeles, California 90095, USA<&wdkj&>Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

语种：

中文

关键词：

心惠通方;冠心病;网络药理学;网络分析;生物信息学

关键词(英文)：

Bioinformatics;Coronary heart disease;Network analysis;Network pharmacology;Xin Hui Tong Formula (XHTF)

期刊：

数字中医药(英文)

ISSN：

2096-479X

年：

2019

卷：

期：

页码：

86-96

DOI：

10.1016/j.dcmed.2019.09.003

基金类别：

We thank for the funding support from the National Natural Science Foundation of China (No. 81373551 ), Hunan Natural Science Foundation (No. 2019JJ40214 ), Hunan Provincial Health and Family Planning Commission (No. 20190638 ), Hunan Provincial Brain Hospital (No. 2018B07 ), Innovation of Graduate Students in Hunan University of Traditional Chinese Medicine (No. 2018CX05 and No. 2018CX25 ) and Postgraduate Innovation in Hunan Province (No. CX20190536 and No. CX20190591 ).

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

中医诊断研究所

摘要：

目的采用网络药理学和生物信息学方法,研究心惠通方(XHTF)治疗冠心病可能的分子机制。方法通过Therapeutic Target Database, Drugbank 等构建冠心病的靶点网络, TCMSP 挖掘XHTF 药效分子-靶点网络及XHTF 药效分子-冠心病靶点网络,采用GO 分析及KEGG 通路富集分析工具从多个角度探索XHTF 治疗冠心病的多靶点作用机制和分子调控网络。结果利用TherapeuticTargets Database 及Drugbank 数据库共获得88 个冠心病的靶点。从TCMSP 数据库检索到XHTF393 个化合物以及对应的205 个药物靶点;通过相关数据库共检索到XHTF 可直接作用于13 个冠心病的靶点,分别为: TP53、MAPK14、NFKB1、HSPA5、PLG、PTGS2、...

摘要(英文)：

Objective: To investigate the potential molecular mechanism of Xin Hui Tong Formula (XHTF) in the treatment of coronary heart disease (CHD) by using network pharmacology and bioinformatics. Methods: The targets network of CHD was constructed through Therapeutic Targets Database (TTD) and Drugbank database; The XHTF pharmacodynamic molecule-targets network and the XHTF pharmacodynamic molecule-CHD targets network were explored by the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). And the multi-targets m...

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Network Pharmacology-based Analysis on the Molecular Biological Mechanisms of Xin Hui Tong Formula in Coronary Heart Disease Treatment

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