期刊论文

Zhang Guo-Min

中文

数字中医药(英文)

2096-479X

2020

3

3

163-179

10.1016/j.dcmed.2020.09.003

We thank for the funding support from the National Natural Science Foundation of China (No. 81973670 ), the Natural Science Foundation of Hunan Province (No. 2018JJ2297 ), the Key Program of Scientific Research Fund of Hunan Provincial Education Department (No. 19A370 ) and the Project of Research Learning and Innovative Experiment for College Students in Hunan (No. 2016284 , No. 2016281 , No. 2017281 and No. 2018420 ).

本校为第一且通讯机构

目的 采用网络药理学方法筛选麻杏石甘汤对流感的作用靶点及信号通路,从而预测麻杏石甘汤抗流感的潜在机制.方法 通过检索中药系统药理数据库(TCMSP)及相关文献、设定一定条件筛选主要化合物和主要化合物所对应的靶点.从STRING数据库预测成分靶标蛋白质的互相作用.利用WebGestalt平台和reatome数据库分别对麻杏石甘汤作用于流感的PPI网络中涉及的核心靶点进行GO功能富集分析和KEGG途径分析.用iGEMDOCK对受体和配体进行对接后获得相应的对接分数,对接结果通过Autodock及PyMOL可视化处理.结果 筛选获得126种主要化合物及其所对应的靶点.从STRING数据库预测到355个流感的靶标蛋白和 1 221条流感的蛋...

Objective: Pharmacological methods were used to screen targets and signaling pathways of Ma Xing Shi Gan Decoction (MXSGD) during influenza treatments, and mechanisms underlying anti-influenza effects were elucidated. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and relevant literature were searched under predefined conditions to identify the main compounds and their targets. Interactions between the target proteins were predicted using the STRING database. Gene Ontology (GO) functional e...