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Dioscin inhibits ischemic stroke-induced inflammation through inhibition of the TLR4/MyD88/NF-B signaling pathway in a rat model

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成果类型:
期刊论文
作者:
Zhu, Shilin;Tang, Siyuan*;Su, Feng*
通讯作者:
Tang, Siyuan;Su, Feng
作者机构:
[Zhu, Shilin] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Neurol, Changsha 410005, Hunan, Peoples R China.
[Tang, Siyuan] Cent S Univ, Xiang Ya Nursing Sch, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
[Su, Feng] Cent S Univ, Xiang Ya Hosp, Dept Emergency, 87 Xiang Ya Rd, Changsha 410008, Hunan, Peoples R China.
通讯机构:
[Tang, Siyuan; Su, Feng] C
Cent S Univ, Xiang Ya Nursing Sch, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
Cent S Univ, Xiang Ya Hosp, Dept Emergency, 87 Xiang Ya Rd, Changsha 410008, Hunan, Peoples R China.
语种:
英文
关键词:
Dioscin;Inflammation;Ischemic stroke;Myeloid differentiation factor 88;Nuclear factor-κb;Toll-like receptor 4
期刊:
Molecular Medicine Reports
ISSN:
1791-2997
年:
2018
卷:
17
期:
1
页码:
660-666
机构署名:
本校为第一机构
院系归属:
第二中医临床医学院
摘要:
Diosgenin, as an essential natural steroidal saponin, can be extracted from numerous sources, primarily from fenugreek. It is an important raw material for the synthesis of steroid hormone drugs. It exhibits antitumor, antiinflammatory, antioxidation and several other significant pharmacologic actions, and is of high pharmaceutical value. In the present study, the activities and underlying mechanisms of dioscin in the inhibition of ischemic stroke in rats were investigated. Inflammatory responses wer analyzed using ELISA kits and caspase3 and caspase9 activity was analyzed using Caspase3 and c...

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