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Two new sesquiterpene lactone glycosides from Cnicus benedictus

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成果类型:
期刊论文
作者:
Peng, Ying;Jian, Yuqing;Zulfiqar, Ali;Li, Bin;Zhang, Kaiqiang;...
通讯作者:
Khan, Ikhlas A.;Wang, W;Khan, IA
作者机构:
[Cai, Xiong; Peng, Caiyun; Wang, Wei; Long, Fei; Khan, Ikhlas A.; Jian, Yuqing; Peng, Ying; Li, Bin; Zhang, Kaiqiang; Khan, IA] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha, Hunan, Peoples R China.
[Long, Fei; Zulfiqar, Ali; Khan, Ikhlas A.; Peng, Ying; Khan, IA; Zhang, Kaiqiang] Univ Mississippi, Sch Pharm, Dept BioMol Sci, Natl Ctr Nat Prod Res,Div Pharmacognosy, University, MS 38677 USA.
通讯机构:
[Wang, W ; Khan, IA] H
[Khan, IA ] U
Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha, Hunan, Peoples R China.
Univ Mississippi, Sch Pharm, Dept BioMol Sci, Natl Ctr Nat Prod Res,Div Pharmacognosy, University, MS 38677 USA.
语种:
英文
关键词:
11beta,13 dihydrosalonitenolide 15 o beta dextro glucoside;3 hydroxy 2 methyl 4 butanolide;8alpha hydroxy 11beta,13 dihydro onopordaldehyde;amphotericin B;antibiotic agent;antifungal agent;apigenin;ciprofloxacin;cirsimaritin;cnicin;isokaempferide;kaempferol 3 methyl ether 7 o beta dextro glucoside;melitensin;melitensin 15 o beta dextro glucoside;natural product;plant glycoside;sesquiterpene lactone derivative;unclassified drug;antifungal agent;glycoside;lactone;sesquiterpene;aerial plant part;antibacterial activity;antifungal activity;Article;Aspergillus fumigatus;bacterial strain;Candida albicans;carbon nuclear magnetic resonance;Cnicus;Cnicus benedictus;column chromatography;controlled study;Cryptococcus neoformans;drug hydrolysis;drug isolation;drug structure;drug synthesis;Enterococcus faecalis;fungus growth;heteronuclear multiple bond correlation;heteronuclear single quantum coherence;high performance liquid chromatography;IC50;Klebsiella pneumoniae;medicinal plant;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;nonhuman;nuclear Overhauser effect;proton nuclear magnetic resonance;Pseudomonas aeruginosa;vancomycin resistant Enterococcus;Centaurea;chemical structure;chemistry;Cnicus;drug effects;isolation and purification;Antifungal Agents;Aspergillus fumigatus;Centaurea;Cnicus;Glycosides;Inhibitory Concentration 50;Lactones;Molecular Structure;Sesquiterpenes
期刊:
Natural Product Research
ISSN:
1478-6419
年:
2017
卷:
31
期:
19
页码:
2211-2217
基金类别:
Education Department of Hunan Province [13k077]; Hunan Science and Technology Department Funds [2014SK4037, 2014FJ1007]; TCM stem cell laboratory of HUCM
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
Two new sesquiterpene lactone glycosides, namely melitensin 15-O-β-D-glucoside (1) and 11β,13-dihydrosalonitenolide 15-O-β-D-glucoside (2), along with eight known compounds (3–10) were isolated from the aerial part of Cnicus benedictus L. Their structures were elucidated from analyses of extensive spectroscopic data. Compounds 1–6 all possessed an α-methyl-γ-lactone moiety. Moreover, compound 5 exhibited moderate activity against the growth of Aspergillus fumigatus, with IC50 values of 17.67μgmL−1. © 20...

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