期刊论文

Effects of Buyang Huanwu Decoction on Nerve Function and Cell Morphology in Experimental Rats with Cerebral Ischemia

中文

中国实验方剂学杂志

1005-9903

2013

19

2

251-254

10.13422/j.cnki.syfjx.2013.02.077

国家自然科学基金项目(81072939) 湖南省科技计划项目(2011SK3103) 湖南省自然科学基金(12JJ5046)

本校为第一机构

目的:探讨补阳还五汤对局灶性脑缺血大鼠的神经保护作用。方法:189只大鼠随机分为假手术组、模型组和补阳还五汤组,每组63只,常规饲养1周后,采用线栓法制备脑缺血大鼠模型。补阳还五汤组动物于术后2 h后开始给药,给药剂量为5 g.kg-1.d-1,每日ig 1次。各组又分为三个亚组即分别于给药后7,14,21 d 3个时间点处死动物,观察各组不同时间点的脑梗死面积、神经功能评分及脑组织形态学变化。结果:各时间点补阳还五汤组脑梗死面积明显小于同时相模型组,其神经功能评分也均较模型组,差异具有统计学意义（P

Objective： To explore the protective effects of Buyang Huanwu decoction on focal cerebral ischemia in rat. Method： One hundred and eight-nine SD rats were randomly divided into sham operation group, model group and Buyang Huanwu decoction group （n = 63）. One week after the regular feeding, cerebral ischemia animal models was established. Buyang Huanwu decoction was given 2 h after operation （the dose of 5 g ~ kg-1 d-1 ig 1 times per day）. Each group was divided into three sub-groups namely 7 days after administration, 14, 21 d three time ...