Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion——From the perspective of glial-vascular unit

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成果类型：

期刊论文

作者：

Zhou, Chang;Li, Jin-xia;Zheng, Cai-xing;Zhou, Xiao-qing;Chen, Cong;...

通讯作者：

Li, H;Liu, WH

作者机构：

[Li, Hua; Chen, Cong; Zhou, Xiao-qing; Qiu, Shi-wei; Liu, Wang-hua; Li, Jin-xia; Zhou, Chang; Zheng, Cai-xing] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Li, Hua; Liu, Wang-hua; Zhou, Chang] Key Lab TCM Diagnost Hunan Provine, Changsha 410208, Hunan, Peoples R China.

[Zhou, Chang] Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

[Liu, Wang-hua] Key Lab TCM Heart & Lung Syndrome Differentiat & M, Changsha 410208, Hunan, Peoples R China.

[Liu, Wang-hua] Hunan Engn Technol Res Ctr Med & Funct Food, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Li, H ; Liu, WH ] H

Hunan Univ Tradit Chinese Med, 300 Bachelor Rd,Hanpu Sci & Educ Pk, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Bachelor Rd,Hanpu Sci & Educ Pk, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Ischemic stroke;Microglial;Pyroptosis;Inflammation;Glial-vascular unit

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2024

卷：

318

期：

Pt B

页码：

116990

DOI：

10.1016/j.jep.2023.116990

基金类别：

National Natural Science Foundation of China [2023JJ30451]; Natural Science Foundation of Hunan Province [2021013]; Key Items of the Research Program of Chinese Medicine in Hunan Province [A2023038, 20K097]; Hunan Provincial Department of Education Innovation Platform Open Fund Project [2022CX53]; Hunan University of Chinese medicine Postgraduate Inno- vation Project; [81473567]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Ischemic stroke poses a serious risk to public health and quality of life. Jie-Du-Huo-Xue decoction (JDHXD) is a classical and well-known Chinese formula for stroke treatment, but the pharmacological mechanism is still unclear. AIM OF THE STUDY: This study aims to investigate the mechanism underlying microglial pyroptosis and polarization, as well as the potential efficacy of JDHXD against cerebral ischemia-reperfusion injury (CIRI). MATERIALS AND METHODS: Models of CIRI were established by the middle cerebral artery occlusion/reperfusion (MCAO/R) method in rats...

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Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion——From the perspective of glial-vascular unit

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