期刊论文

中文

中医学报

1674-8999

2015

5

719-721

10.16368/j.issn.1674-8999.2015.05.248

湖南省教育厅重点课题（11A089） 湖南省中医药管理局重点课题（201148）

本校为第一机构

目的：观察前癃通对体外培养前列腺间质细胞Fibronectin与CollagenⅣ基因表达的影响，为中药复方治疗良性前列腺增生症提供实验依据。方法：15例前列腺增生症患者按门诊就诊号从中随机选取5位患者，给药前静脉采血、抗凝、离心，提取血浆作为空白组。再按门诊就诊号将所选15例患者随机平均分为前癃通高剂量组、中剂量组、低剂量组，高剂量组口服前癃通每次6粒，中剂量组每次3粒，低剂量组每次1．5粒，均为3次＆#183;d－1，连续服药7 d。末次服药2 h后，静脉采血、抗凝、离心提取含药血浆。免疫荧光检测鉴定间质细胞，实时荧光定量PCR技术检测4组间质细胞Fibronectin和Collagen Ⅳ基因表达。结果...

Objective:To investigate the effects of Qianlongtong Capsule drug-containing plasma on Fibronectin and Collagen Ⅳ gene of prostate stromal cells in vitro,provided experimental theoretical basis for Chinese herbal compound treating benign prostatic hyperplasia (BPH).Methods:We selected 15 cases of patients in clinic,selected 5 patients according to the number of outpatients randomly select-ed from them,venous blood,anticoagulation,centrifugal,extract plasma as blank control group before oral administration.Divided select-ed 15 patients into hig...