Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Lin;Zhong, Senjie;Ye, Jiahao;Hu, Siyuan;Xiong, Xiajun;...

通讯作者：

Hu, ZX

作者机构：

[Hu, Zhixi; Li, Lin; Hu, ZX; Ye, Jiahao; Hu, Siyuan] Hunan Univ Chinese Med, Domest First Class Discipline Construct Project Ch, Dept Nephrol, Changsha, Hunan, Peoples R China.

[Hu, Zhixi; Li, Lin; Hu, ZX; Chen, Guangyu; Xiong, Xiajun] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.

[Zhong, Senjie] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.

[Chen, Guangyu] Hunan Engn Technol Res Ctr Med & Funct Food, Changsha, Hunan, Peoples R China.

通讯机构：

[Hu, ZX ] H

Hunan Univ Chinese Med, Domest First Class Discipline Construct Project Ch, Dept Nephrol, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Heart failure;Shenmai injection;Gut microbiota;Fecal metabolomics;TMAO

期刊：

BMC Complementary Medicine and Therapies

ISSN：

2662-7671

年：

2025

卷：

期：

页码：

1-21

DOI：

10.1186/s12906-024-04737-2

基金类别：

The Natural Science Foundation of Changsha (grant number kq2208185), the Natural Science Foundation of Hunan (grant number 2023JJ30453), the Natural Science Foundation of China (grant number 82274412), The science and technology innovation Program of Hunan Province (2024RC3199), Additionally, the Excellent Young Scholars Research Fund Project of Hunan University of Chinese Medicine provided funding for this project (Z2023XJYQ03).

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

中医诊断研究所

摘要：

Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality and morbidity rates globally. Shenmai injection (SMI), a form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF. Recent research suggests that Traditional Chinese Medicine (TCM) may induce beneficial changes in microbial-host co-metabolism, potentially providing cardiovascular protection. This study used a rat model of hypertensive heart failure (H-HF) to explore the mechanism of SMI. The possible compounds and key targets of SMI against H-HF were inves...

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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism

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