Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Dong;Zhao, Deyao;Li, Jinhui;Wu, Yuting;Du, Lili;...

通讯作者：

Huang, YY

作者机构：

[Wu, Yuting; Li, Jinhui; Li, Zhihong; Huang, Dong; Du, Lili; Zhao, Deyao] Peking Univ, Natl Key Lab Sci & Technol Micro Nano Fabricat, Inst Microelect, Inst Mol Med, Beijing 100871, Peoples R China.

[Li, Xiaoqiong; Huang, YY; Deng, Yulin; Huang, Yuanyu] Beijing Inst Technol, Minist Ind & Informat Technol, Key Lab Mol Med & Biotheranot, Adv Res Inst Multidisciplinary Sci,Sch Life Sci, Beijing 100081, Peoples R China.

[Xia, Xin-Hua] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Huang, YY ] B

Beijing Inst Technol, Minist Ind & Informat Technol, Key Lab Mol Med & Biotheranot, Adv Res Inst Multidisciplinary Sci,Sch Life Sci, Beijing 100081, Peoples R China.

语种：

英文

关键词：

Drug delivery;gene therapy;chaotic microfluidics;nanoneedle array;staggered herringbone channel;microfluidic chip

期刊：

CURRENT DRUG DELIVERY

ISSN：

1567-2018

年：

2019

卷：

期：

页码：

164-170

DOI：

10.2174/1567201815666181017095044

基金类别：

This work was supported by the National Natural Science Foundation of China (91323304, 81402863, 31871003), the National Key Research and Development Program of China (No. 2016YFA0200802), and the Beijing Institute of Technology Research Fund Program for Young Scholars and the Fundamental Research Funds for the Central Universities, the Hunan Provincial Natural Science Foundation of China (2018JJ1019), and the Hu-Xiang Young Talent Program (2018RS3094).

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Background: Delivery of foreign cargoes into cells is of great value for bioengineering research and therapeutic applications. Objective: In this study, we proposed and established a carrier-free gene delivery platform utilizing staggered herringbone channel and silicon nanoneedle array, to achieve high-throughput in vitro gene transfection. </P><P> Methods: With this microchip, fluidic micro vortices could be induced by the staggered-herringboneshaped grooves within the channel, which increased the contact frequency of the cells with the channel substrate. Transient disruptio...

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Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array

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