期刊论文

中文

中国中西医结合耳鼻咽喉科杂志

1007-4856

2004

12

6

296-297

10.16542/j.cnki.issn.1007-4856.2004.06.003

30171174,30271678:国家自然科学基金 02-03JP29:国家中医药局科研项目 01A014;2001]198;A0109:湖南省教育厅科学研究项目

本校为第一机构

目的探讨nm23-H1基因蛋白表达与鼻咽癌颅内转移的关系.方法用nm23-H1单克隆抗体对68例鼻咽癌患者的102份标本进行免疫组织化学染色(SP)法,检测nm23-H1蛋白的表达.结果在鼻咽癌中,nm23-H1蛋白表达与颅内转移的发生及预后均有明显相关性(P＜0.05).结论原发肿瘤中nm23-H1表达下降对脑转移癌的发生及预后具有重要意义,检测鼻咽癌组织中nm23-H1蛋白表达水平可能是预测鼻咽癌颅内转移及预后的重要指标.

Objective To investigate the prognostic association of nm23-H1 expression with intracranial metastasis of nasopharyngeal carcinoma (NPC). Methods The expressive level of nm23-H] protein was detected by immunohisto chemical assay (SP procedure) with the use of monoclonal antibody against nm23-H1 among 102 samples collected from 68 cases of NPC. Results Among these cases with NPC,the expressive level of nm23-H1 protein in the cancerous tissues in nasopharynx was significantly associated with the occurrence of intracranial metastasis from NPC (P