Conceptualization, D.T.W.W., F.L. and W.-C.S.; Methodology, F.L., F.W.; Validation, F.L., F.W., L.L., M.M.S., M.T. and J.H.T.; Formal Analysis, Q.Y. and Z.F.; Resources, W.-L.H. and C.-C.L., W.L.; Data Curation, F.L., Q.Y.; Writing—Original Draft Preparation, M.M.S., F.L.; Writing—Review and Editing, F.L., D.T.W.W., F.W., Y.K., D.C., Z.F.; Visualization, M.M.S., F.L., Q.Y.; Supervision, D.T.W.W., F.L. and W.-C.S.; Project Administration, D.T.W.W.; Funding Acquisition, D.T.W.W., F.L. All authors have read and agreed to the published version of the manuscript. This work is supported by NIH R21 CA239052, UH3 TR000923 and UH2 CA206126, U01 CA233370.