期刊论文

Shen, J

英文

Clinica Chimica Acta

0009-8981

2019

499

149-153

10.1016/j.cca.2019.09.011

In conclusion, apelin/APJ system, as a novel activity regulator, is involved in the regulation of neurohumoral fluid in the endocrine system, especially the hypothalamic-pituitary axis. In this review, we summarize the expression of apelin and APJ in the hypothalamus, pituitary, thyroid, adrenal, ovarian, and testicular tissues. In addition, we further explored its effect on endocrine diseases by affecting these signal axes. It is worthy of our attention that the difference in apelin

本校为其他机构

Apelin and its G protein-coupled receptor APJ are specifically expressed in endocrine organs. As well known, the hypothalamus is the regulatory center of endocrine activity, which combined with the pituitary and other gonads form regulatory axes involved in endocrine function. Evidence to date has shown that the apelin/APJ system plays an important role in mediating these axes, such as food intake, acute stress, steroid release, as well as, an anti-depressant-like activity. Here we review the effect of the apelin/APJ system on hypothalamic-pituitary-thyroid, hypothalamic-pituitary-adrenal and ...