Objective: To study the optimal conditions of the water extracting and alcohol precipitation techniques for Eczema Spray.Methods: The content of Matrine were used as the assessment markers.The water extracting and alcohol precipitation techniques for Eczema Spray was optimized with orthogonal design experiment.Results: The optimal technological parameters of the alcohol precipitation techniques for Cynanchum paniculatum and Radix sophorae flavescentis were as follows: the ratio between medicinal materials and solvent is 1 to 0.57,the percen...