Objective:To study the flocculation process with chitosan for Xiang A-2 Granules. Methods On the basis of the one-factor investigation such as the amount of chitosan, the concentration and pH of the extracting solution, temperature and stirring etc, the experiments for the further optimization of flocculation process conditions were arranged with orthogonal design. Results: The optimal flocculation process conditions were as follows. The adding amount of chitosan was 0.6 mL·g^- 1, the extract solution and medicinal materials were in the rati...