期刊论文

中文

中国实验方剂学杂志

1005-9903

2009

15

9

10-13

10.3969/j.issn.1005-9903.2009.09.005

本校为第一机构

目的:对经微粉化制备的枳术丸与枳术丸进行显微、理化鉴别、溶出情况对比研究,探索超微粉碎对丸剂质量的影响。方法:采用TLC法鉴别枳实与白术、采用HPLC法测定枳术丸橙皮苷的体外溶出情况,并采用了Weibull分布模型进行溶出动力学模拟。结果:超微粉碎与普通粉碎后TLC无显著差别,经微粉化制备的枳术丸各时间点的有效成分溶出较普通丸剂快。结论:枳术丸经超微粉碎后橙皮苷溶出量增加,溶出速度明显提高。

Objective： To search for the micronization impact to the pill preparation, we carry out a series of comparative study on the micro characteristic,TLC characteristic,dissolution results of Ultro-micro and Normal powder of Zhizhu pill. Method： Using Fructus Aurantii Immaturus and Rhizoma Atractylodis Macrocephalae, the TLC information can be identified. Taking Hesperidin as the index component, the dissolution character were compared. The Weibull distribution analysis system were also applied. Result：We can see the almost similar TLC character...