期刊论文

Effect of Yuxianling Granules on the NGF of Hippocampus and Cognitive Function in Rats with Epilepsy Induced by Pentylenetetrazol

中文

中国实验方剂学杂志

1005-9903

2010

6

184-187

10.3969/j.issn.1005-9903.2010.06.058

湖南省自然科学基金资助项目（08JJ5001） 湖南省教育厅重点课题资助科研项目（06A051）

本校为第一机构

目的：探讨愈痫灵颗粒对痫性大鼠海马区神经生长因子（nerve growth factor,NGF）及认知功能的影响。方法：选取150只清洁级SD大鼠,随机选取10只作为正常组;其余动物用戊四氮（PTZ）造模。将符合模型标准的大鼠随机分为4组,ig给药,即愈痫灵颗粒组、丙戊酸钠组、拉莫三嗪组给药剂量分别为810 mg·kg^-1,122 mg·kg^-1,10.1 mg·kg^-1,模型组、正常组每天给予同等体积蒸馏水。每天1次,连续给药28 d后,用开场实验（open field test）测定大鼠认知功能变化,采用免疫组织化学方法观察NGF的表达。结果：与模型组相比,愈痫灵颗粒能显著提高戊四氮致痫大鼠的开场实验成绩,差异有显著统计学意义（P〈0.01...

Objective：To study the effect of Yuxianling granule（YXLG） on the hippocampal nerve growth factor（NGF） and cognitive function in epileptic rats.Method：150 SD rats were used for the experiment,and 10 of them were randomly selected as the blank control group.The rest animals were treated with pentylenetetrazol（PTZ） to establish the model.The rats consisting with the model standard were divided randomly into 4 groups,including model group,YXLG group,sodium valproate group and lamotrigine group..Using gavage administration,the drug doses wer...