期刊论文

Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model

中文

中国实验方剂学杂志

1005-9903

2011

17

24

162-164

10.3969/j.issn.1005-9903.2011.24.046

湖南省中医药科研计划项目（2006-070）；

本校为第一机构

目的：观察芎麻汤不同提取物治疗偏头痛的药理作用。方法：采用小鼠皮下注射1 mg.kg^-1利血平致小鼠偏头痛模型、醋酸致小鼠扭体模型,昆明小鼠随机分为阿米替林组（0.033 g.kg^-1）、芎麻汤水提液组（1.4,5.6 g.kg^-1）、芎麻汤醇提组（1.4,5.6 g.kg^-1）、芎麻汤挥发油组（1.4,5.6 g.kg^-1）,连续给药7 d,观察芎麻汤水提液,挥发油、醇提液对偏头痛模型小鼠血清5-羟色胺（5-HT）含量及镇痛作用的影响。结果：芎麻汤水提液（5.6 g.kg^-1）能明显升高利血平化低5-HT小鼠模型血清中5-HT的含量（P〈0.01）,芎麻汤挥发油（1.4,5.6 g.kg^-1）能明显延长冰醋酸致小鼠扭体潜伏期及减少扭体次数。结论：芎...

Objective： To observe effects of different extracts from Xiongma decoction on migraine.Method： The mice migraine model was induced by,reserpin and acetic acid was used to induce mice writhing model.Mice were injected 1 mg·kg^-1 reserpine to induce migraine model.Mice were randomly divided into amitriptyline group（0.033 g·kg^-1）,extract group of Xiongma decocotion（1.4,5.6 g·kg^-1）,alcohol extract group of Xiongma decoction（1.4,5.6 g·kg^-1）,volatile oil group（1.4,5.6 g·kg^-1）,which were orally given for 7 days.The level of 5-HT and...