期刊论文

中文

中国实验方剂学杂志

1005-9903

2011

17

3

170-173

10.3969/j.issn.1005-9903.2011.03.053

[基金项目]湖南省卫生厅中医药专项基金（2008025） 长沙市科技局计划（K10001044-41）

本校为第一机构

目的:观察舒胃汤对功能性消化不良(functional dyspepsia,FD)大鼠c-Kit阳性Cajal间质细胞(interstitial cells of cajal,ICC)、胃动素(Motilin,MTL)表达的影响,探讨其可能的作用机制.方法:将大鼠随机分成对照组、模型组、舒胃汤高剂、舒胃汤低剂量组、多潘立酮组、木香顺气组,采用夹尾刺激法[1]建立FD大鼠模型,连续给药14 d后,采用免疫组化分析法榆测胃窦MTL和c-Kit阳性ICC表达,以酚红法观察胃排空.结果:与对照组相比,模型组胃排空延迟、胃窦MTL和c-Kit阳性ICC表达显著降低(均P＜0.05);与模型组相比,舒胃汤高剂量组、多潘立酮组及木香顺气绀胃排空、MTL及c-Kit阳性ICC表达显著升高(均P＜0.05),而...

Objective ： To observe the effects and mechanism of Shuweitang on expression of interstitial cells of cajal （ICC） and motilin （MTL） in functional dyspepsia （FD） rats. Method ： FD model was induced by moderate enraging the rats＇ tail. All rats were divided randomly into 6 groups： control group, model group, high and low dosages of Shuweitang groups, domperidone and Muxiangshunqi groups. Drugs were administrated for 14 days. ICC and MTL were determined by immunohistochemical method. And gastric emptying was observed with phenolsulfonpht...