期刊论文

中文

中国实验方剂学杂志

1005-9903

2011

12

110-113

10.3969/j.issn.1005-9903.2011.12.033

本校为第一机构

目的:探讨秦皮甲素在大鼠各肠段的吸收动力学特征。方法:以大鼠在体肠灌流模型从吸收部位、药物浓度考察秦皮甲素的肠吸收动力学情况。结果:秦皮甲素在大鼠各肠段吸收有差异,十二指肠、空肠、回肠中的Ka依次为0.185 0,0.186 5,0.065 7 min-1。结论:秦皮甲素在小肠吸收迅速完全,其吸收呈一级吸收动力学特征且吸收机制为被动转运,适于制成缓释给药系统。

Objective：To investigate the absorption characteristics of aesculin in different intestinal segments of rats.Method：The study was performed by intestinal perfusion model in rats to observe the effect of absorption sites and concentrations on absorption kinetics of aesculin.Result：Aesculin had specific site in rat′s intestine,absorption rate constants were 0.185 0,0.186 5,0.065 7 min-1 in duodenum,jejunum and ileum respectively.Conclusion：Aesculin was rapidly and completely absorbed in whole segments of intestine.The behaviors conformed to ...