期刊论文

Effect of Andrographolide on Vasoactive Substances in Myocardial Hypertrophy Rats

中文

中国实验方剂学杂志

1005-9903

2012

18

12

166-169

10.3969/j.issn.1005-9903.2012.12.048

江西省卫生厅科技项目（20091208）；

本校为第一机构

目的:观察穿心莲内酯(andrographolide,AP)对异丙肾上腺素(isopropylarterenol,Iso)所致大鼠心肌肥厚的保护作用及其对血管紧张素Ⅱ( angiotensinⅡ,AngⅡ)、心钠素(atrial natriuretic peptide,ANP)、内皮素(endothelin,ET)和一氧化氮( nitric oxide,NO)的影响.方法:以Iso1 mg·kg-1背部皮下注射(sc)连续10 d建立大鼠心肌肥厚模型.选模第2天给药组sc给予低、中、高剂量(0.1,0.3,1.0μmol· kg-1)的AP,溶剂组sc二甲基亚砜,正常组和模型组sc给予生理盐水,连续14 d,末次给药后禁食12 h,取血,分离血清及血浆,取心肌组织并制成10％匀浆.酶活性分析法检测血清及心肌组织乳酸脱氢酶(lactate dehydroge...

Objective： To observe the protection of andrographolide （AP） on rat＇s myocardial hypertrophy induced by isopropylarterenol （Iso） , explore balance of vasoactive substance. Method： The rat＇s myocardial hypertrophy model is formed through hypodermic injection which extended 10 days at back skin with Iso, 1 mg· kg^-1· d^-1. Once the model is formed, it will be administrated with various doses of AP, dimethyl sulfoxide （DMSO） or normal saline through hypodermic injection from the second day, and the process will extend 14 days. After th...