期刊论文

Investigation of Solubility Parameter Sampling Method with Chromatographic Pharmacodynamics of Chinese Materia Medica

中文

中国实验方剂学杂志

1005-9903

2012

18

20

6-11

10.13422/j.cnki.syfjx.2012.20.024

81073142:国家自然科学基金 8117358:国家自然科学基金

本校为第一机构

目的:研究不同溶度参数的溶剂对中药复方成分溶出规律,为谱效学制样提供新思路及理论依据.方法:用不同溶度参数溶媒溶解补阳还五汤浸膏,所得溶解物通过HPLC获得其成分的指纹图谱,结合总量统计矩原理,采用总量统计矩相似度法评价不同溶解度参数的溶剂对总方成分溶出液指纹图谱的差异性.结果:样品的零阶矩AUCT、一阶矩λT、二阶矩σ-2r的RSD分别为58.2％,12.8％,24.8％,说明不同溶度参数溶媒溶解所得的化学成分及总量存在明显差异,其总量统计矩标准相似度介于0.370 ～0.998.S4,S5,S6(溶度参数18.33 ～20.60 J1/2·cm-3/2)与其他样品的相似度,以及S7,S8(溶度参数21.73 ～22.87 J1/2·cm -3/2)与除了...

Objective:To study dissolution regular pattern of ingredients from traditional Chinese medicine compound by solvent with different solubility parameter,and provide new ideas and theoretical basis for chromatographic pharmacodynamics sampling.Method: With different solubility parameters of solvent to dissolve Buyang Huanwu decoction extract,fingerprint chromatogram of ingredients from obtained lysate were determined by HPLC,and combining with total statistical moment theory,difference of solvent with different solubility parameter on component s...