期刊论文

中文

中国实验方剂学杂志

1005-9903

2015

21

21

148-151

10.13422/j.cnki.syfjx.2015210148

湖南省新药研发-企业委托课题项目（2014）；

本校为第一机构

目的: 研究补肾疗更浸膏对去势更年期模型大鼠下丘脑β-内啡肽含量与自由基代谢功能的影响,并探讨作用机制。方法: 手术摘除雌性SD大鼠双侧卵巢复制更年期综合征模型,阴道细胞涂片检查模型成功后,将其随机分为正常组,假手术组,模型组,戊酸雌二醇片组(0.18 mg·kg~(-1)),坤泰胶囊组(1.08 g·kg~(-1)),补肾疗更浸膏低、中、高剂量组(4.5,9,18 g· kg~(-1)),每组10只。除正常组、假手术组与模型组小鼠ig给予等量蒸馏水外,各组小鼠按照剂量要求ig给药,每天1次,连续4周。末次给药24 h后,腹主动脉取血,酶联免疫吸附试验(ELISA)法测定大鼠血清超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-Px)活性与丙二...

Objective： To study the effects of Busheng Liaogeng extract on β-endorphin（ β-EP） in the hypothalamus and free radicals of rat model in menopause,and explore the mechanism of action. Method：Climacteric syndrome models were established by surgical removal of the bilateral ovaries of female SD rats. After successful modeling by vaginal smears test,the rats were randomly divided into normal group,sham operation group,model group,estradiol valerate tablets group（ 0. 18 mg·kg- 1）,Kuntai capsule group（ 1. 08 g·kg- 1）,Busheng Liaogeng extr...