期刊论文

中文

中国实验方剂学杂志

1005-9903

2016

22

1

139-142

10.13422/j.cnki.syfjx.2016010139

湖南省高校创新平台开放基金项目

本校为第一机构

目的:研究丹龙醒脑方对脑缺血再灌注大鼠血管新生及血管生成素-1(Ang-1)的影响。方法:用线栓法制备大鼠大脑中动脉栓塞缺血再灌注(MCAO)模型,2 h后开放血流再灌注。大鼠造模成功后被分为6组(丹龙醒脑方14.76,7.38,3.69 g·kg~(-1)剂量组,尼莫地平10.8 mg·kg~(-1)组,模型组,假手术组),ig 7 d后处死大鼠取脑,用免疫组化法测定缺血海马区的内皮细胞数和微血管密度(MVD)及Ang-1的蛋白表达。结果:与假手术组比较,模型组大鼠内皮细胞计数及MVD,Ang-1蛋白表达均明显增强(P

Objective:To investigate the effect of Danlong Xingnao decoction on the angiogenesis and the angiopoitin1(Ang-1) protein expression of rats with cerebral ischemia-reperfusion. Method:A rat model of the middle cerebral artery occlusion/reperfusion (MCAO) was created by using the suture method, and the blood reperfusion was performed 2 hours later. The rats were randomly divided into six groups, high-dose, medium-dose and low-dose (14.76, 7.38, 3.69 g·kg~(-1)) Danlong Xingnao decoction groups, nimodipine (10.8 mg·kg~(-1)) group, model group and...