期刊论文

中文

中国实验方剂学杂志

1005-9903

2016

22

16

1-5

10.13422/j.cnki.syfjx.2016160001

81270055:国家自然科学基金 81573691:国家自然科学基金 2015JJ2111:湖南省自然科学基金 2015CX18:创新基金

本校为第一机构

运用中药谱动学研究方法对金银花、山银花的生物等效规律进行探索求证。方法:通过口服给药的方式,对3组SD大鼠分别给予金银花提取液、山银花提取液和水2 mL,分别于给药后0.25,0.5,1,1.5,2,3,4,6,8,12,24 h后取血,通过HPLC测定血样中药物的代谢指纹图谱,运用谱动学公式计算药物动力学参数与谱动学参数。结果:金银花谱动学总量零阶矩、整体药物代谢一阶矩、整体药物代谢二阶矩、指纹图谱特征峰总量一阶矩和指纹图谱特征峰总量二阶矩参数分别为1 621.014 μg·min·L~(-1),12.632 min,34.717 min~2,16.088 min和16.626 min~2;山银花谱动学这些参数分别为1 769.339 μg·min·L~(-1),13.308 min,38....

Objective： To explore and confirm the bioequiavailability between Lonicerae Japonicae Flos and Lonicerae Flos,and provide a new solution for the dispute between them. Method： Three groups of rats were treated with 2 mL of Lonicerae Japonicae Flos extract,Lonicerae Flos extract and ultrapure water by oral administration,respectively.Blood taking time points were 0.25,0.5,1,1.5,2,3,4,6,8,12,24 h,then determined by HPLC and calculated pharmacokinetic parameters and spectral parameters by chromatokinetics formula. Result： Total amount of zero-or...