期刊论文

Effect of Juanbi Lijieqing Formula on TLR4, NF-κB and PPARγ in Synovial Membrane of Rats with Amelioration of Gouty Arthritis

中文

中国实验方剂学杂志

1005-9903

2018

24

23

126-133

10.13422/j.cnki.syfjx.20182332

国家自然科学基金项目（81574005）；

本校为第一机构

目的:观察蠲痹历节清方对改良痛风性关节炎大鼠滑膜组织中Toll样受体4(Toll-like receptors 4,TLR4),核转录因子kappa B(nuclear factor-kappaB,NF-κB),过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor γ,PPARγ)的影响,探讨蠲痹历节清方治疗急性痛风性关节炎局部组织炎症的可能作用机制。方法:将42只SD雄性大鼠,按随机数字表法选取6只为正常组,30只为造模组,造模组采用改良痛风性关节炎造模后随机分为模型组,蠲痹历节清方高、中、低剂量组(4 400,2 200,1 100 mg·kg~(-1)),依托考昔组(11 mg·kg~(-1)),吡格列酮组(20 mg·kg~(-1)),每组6只。正常组及模型组的大鼠以...

To observe the effect of Juanbi Lijieqing formula on Toll-like receptors 4(TLR4), nuclear factor-kappa B (NF-κB), peroxisome proliferator-activated receptor γ(PPARγ)in synovial tissue of modified gouty arthritis rats, in order to explore the possible mechanism of Juanbi Lijieqing formula in the treatment of acute gouty arthritis with local tissue inflammation. Method: Among 42 male SD rats, 6 were selected as blank group according to the random number table method, 30 were included in the modeling group. The modeling group was randomly divid...