期刊论文

Exosomes in Colorectal Cancer

中文

中国实验方剂学杂志

1005-9903

2018

24

6

182-188

10.13422/j.cnki.syfjx.20180672

81373602:国家自然科学基金 81774287:国家自然科学基金 2017CT5029:中央引导地方科技发展专项

本校为第一机构

大肠癌是发病率最高的消化道恶性肿瘤之一,总体5年生存率不高,且近年来随着饮食结构等的改变,大肠癌在我国发病率逐年上升,严重威胁着人类生命健康,故研究大肠癌发生、发展的机制及有效防治方法有重大意义。外泌体是一类由细胞分泌的直径约30~100 nm的有被小泡,表面携带特定分子,可通过受体-配体结合方式或通过内吞作用被内在化,或与靶细胞膜融合,将囊泡中的物质释放至靶细胞胞液中,诱导靶细胞生理状态发生改变,在细胞与细胞间的交流中发挥重要作用。在肿瘤组织中,外泌体作为肿瘤微环境的重要组成部分,可通过促进肿瘤新生血管形成、促使结直肠癌细胞上皮-间质转化、引导肿瘤细胞器官特异性转移、...

Colorectal cancer has the highest incidence among malignant digestive tract tumors, with a low survival rate in five years. In recent years, with the changes in diet structure, its incidence has increased in China year by year, and become a serious threat to human health. Therefore, it is of great significance to study its occurrence and development mechanisms and effective prevention and treatment methods. Exosomes are a type of secretory vesicles with a diameter of about 30-100 nm secreted by cells, and carry specific molecules on surface. They can be internalized through receptor-ligand bin...