期刊论文

Research on Quality Control Model of Ancient Famous Classical Formulas Based on Supramolecular Theory

中文

中国实验方剂学杂志

1005-9903

2019

25

16

161-166

10.13422/j.cnki.syfjx.20191652

81573691:国家自然科学基金 81703824:国家自然科学基金 2017JJ3236:湖南省自然科学基金 17B200:湖南省教育厅项目 CX2018B504:湖南中医药大学研究生科研创新项目 2018CX18:湖南中医药大学研究生科研创新项目

本校为第一机构

古代经典名方是基于疗效优、毒副作用小、临床上广泛应用的特点进行研发,其发展将切实推动中医药的应用,具有重要的社会效益和经济效益。中药及中药复方是多成分体系,通过多成分、多靶点和多途径作用于人体,其疗效是多成分协同作用的结果,如何在中药多成分的生物学性质基础上,阐述药材-饮片-制剂制备过程及质量属性显得非常关键。中药和人体均是巨复超分子体,其成分是反映原生物体"印迹模板"特征聚集客体,具有遗传多态性。中药质量属性、炮制、制剂制备与质量属性评价都受到超分子化学的影响,最终反映到"印迹模板"的制备及其质量属性的传递规律上。因此,经典名方研发时运用超分子"印迹模板"理论...

The ancient famous classical formulas were developed based on the characteristics of excellent curative effect, small toxic and side effects, and wide clinical application. Its development will promote the development of traditional Chinese medicine (TCM) with huge social and economic benefits. TCM and TCM compounds are multi-component systems, which are multi-component, multi-target and multi-pathway effect on human body, their curative effect is the result of synergistic effect of multi-component. Because of its characteristics, its mechanism of action is still unclear and quality is difficu...