期刊论文

Consistency Analysis of "Imprinting Templates" of Chinese Medicine Preparations Based on Dynamic Volatile Components in Houttuyniae Herba

Liu, W.-L.;He, F.-Y.

中文

中国实验方剂学杂志

1005-9903

2019

25

14

150-155

10.13422/j.cnki.syfjx.20190446

81573691:国家自然科学基金 81703824:国家自然科学基金 2016JJ405:湖南省自然科学基金 2016TP1017:湖南省科技厅重点项目 :湖南省教育厅协同创新中心建设项目

本校为第一机构

目的:通过阐明不同批次鱼腥草挥发性成分种类与含量的动态变化规律,揭示中药复方制剂“印迹模板”的均一性规律,为有效地控制中药复方制剂的质量提供实验依据。方法:采用水蒸气蒸馏法提取鱼腥草挥发油,采用GC-MS检测(电子轰击离子源,离子源温度230℃,检测范围m/z 40~500),并结合文献及Chemical Book数据库分析11批鱼腥草的挥发性成分,以面积归一化法计算各成分的相对质量分数,并对指纹图谱进行总量统计矩分析。结果:在11批鱼腥草挥发油中,共有成分仅15个,占成分总数的3. 35%,总相对质量分数平均值73. 94%;而非共有成分却有433个,占总数的96. 65%。GC-MS指纹图谱总量一阶矩的RSD 6. 8%,总量二阶矩...

Objective; The homogeneity regularity of "imprinting templates" of compound preparation of traditional Chinese medicine (TCM) was revealed, which provided the basis for effectively controlling the quality of compound preparation of TCM, by clarifying the dynamic changeability in number and content of volatile ingredients in different batches of Houttuyniae Herba. Method; The volatile oil of Houttuyniae Herba was extracted by steam distillation. The volatile components in 11 batches of Houttuyniae Herba were determined by GC-MS (electron ionizat...