期刊论文

Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang

中文

中国实验方剂学杂志

1005-9903

2019

25

15

37-43

10.13422/j.cnki.syfjx.20191462

81573691:国家自然科学基金 81703824:国家自然科学基金 81874507:国家自然科学基金 2017JJ3236:湖南省自然科学基金 2016JJ2097:湖南省自然科学基金 :湖湘中药资源保护与利用协同创新中心建设项目

本校为第一机构

目的:建立中药及经典名方HPLC指纹图谱总量统计矩、信息量及一次投料量数学模型并进行实验验证。方法:运用总量统计矩原理和Hardy-Weinberg平衡群体一次稳态投料量计算方法,对来自不同产地的15批桃红四物汤原药材、饮片及复方制剂总量统计矩及一次稳态投料量进行研究。结果:除了总量一阶矩外,各药材、饮片及复方总量零阶矩、总量二阶矩、信息熵、信息量的RSD均> 10%。用单味原药材投料,除当归外（142. 34 kg）,按全方累积的信息量的RSD变化计算出的一次稳态投料量最大（59. 10 kg）;而按全方的比例投料,全方一次稳态投料量最大（958. 57 kg）。用炮制品投料,除酒红花外（83. 28 kg）,全方累积的...

Objective: To establish a mathematical model of total statistical moment, information amount and one-time steady-state feeding quantity of HPLC fingerprint of traditional Chinese medicines (TCMs) and their classical prescriptions, and to carry out experimental verification. Method: The total statistical moment principle, Hardy-Weinberg equilibrium principle and one-time steady-state feeding quantity calculation method were used to study the total statistical moment parameters and one-time steady-state feeding quantity of 15 batches of original medicinal materials, decoction pieces and compound...