期刊论文

Current Research Status of Aptamer-mediated Liposome Targeted Delivery of Antitumor Drugs

中文

中国实验方剂学杂志

1005-9903

2020

26

20

206-212

10.13422/j.cnki.syfjx.20201554

81573621:国家自然科学基金 CX20190574:湖南省研究生科研创新项目 19C1427:湖南省教育厅科学研究项目 2019JJ50438:湖南省自然科学基金

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肿瘤已成为危害人类健康和生命的第二大疾病,化学药物治疗(简称化疗)是最基本的治疗手段,但大多数化疗药物会对正常组织造成损害。如何更高效地递送抗肿瘤药物,提高药物在肿瘤部位的浓度,增强抗肿瘤作用,同时减少其在正常组织中的分布以减少对正常组织的损伤,是生物医药研究领域的难题。为实现抗肿瘤药物的精准递送并达到增效减毒的目标,研究人员利用指数富集的配体系统进化技术(SELEX技术)筛选可特异性靶向肿瘤标志物或肿瘤细胞的核酸适配体,设计了以适配体为靶向分子(配体)的新型脂质体靶向递药系统。笔者对核酸适配体技术与常见的肿瘤标志物进行了简要介绍,并对适配体-脂质体递药系统的抗肿瘤...

Tumor has become the second most serious disease that threatens human health and life.Treating with chemical drugs(referred to as chemotherapy)is the most basic treatment,but most chemotherapeutic drugs cause damage to normal tissues.It is a difficult problem in the field of biomedical research that how to deliver anti-tumor drugs more efficiently,increase the concentration of drugs in tumor tissues,enhance the anti-tumor effect,and decrease the drug distribution in normal tissues to weaken the damage to normal tissues.In order to achieve the goals of accurate delivery of anti-tumor drugs and ...