期刊论文

Effect of Modified Shaoyao Gancaotang,Electroacupuncture and Acupuncture Combined with Herb onγ-Aminobutyric Acid Related Receptor Proteins in Cortex in SCA Rats

中文

中国实验方剂学杂志

1005-9903

2020

26

17

29-35

10.13422/j.cnki.syfjx.20201739

81673886:国家自然科学基金 2018JJ2294:湖南省自然科学基金 201862:湖南省中医药科研项目

本校为第一机构

目的:分析脑卒中痉挛状态(SCA)大鼠肌张力损伤情况与大脑皮质区γ-氨基丁酸α受体(GABAα),γ-氨基丁酸转运体(GAT-1)蛋白及mRNA表达情况,探讨加味芍药甘草汤、电针曲池、阳陵泉穴位及针药结合3种方法缓解脑卒中肢体痉挛的疗效.方法:通过2次随机分组,分为空白组、假手术组、模型组、加味芍药甘草汤组、针药结合组、电针组,每组9只.采用改良Zea-Longa线栓法+内囊注射NMDA受体法制备脑卒中肢体痉挛大鼠模型,行为学评分确认模型成功后,分别对电针组(电针双侧阳陵泉、曲池,30 min/次/d,持续5 d),加味芍药甘草汤组(加味芍药甘草汤水煎剂1次/d,每次灌胃10 mL·kg-1,持续5 d),针药结合组(加味芍药甘草汤...

Object:To analyze the effect of muscular tension injury in spasticity of cerebral apoplexy(SCA)rats with spasticity and the expression of γ-aminobutyric acid receptor(GABAα),γ-aminobutyric acid transporter (GAT-1) protein and mRNA expression in cerebral cortex modified Shaoyao Gancaotang,electroacupuncture Quchi,Yanglingquan and acupuncture combined with herb therapies alleviate the effect of SCA.Method:Randomly divided into two groups,divided into blank group,sham operation group,model group,modified Shaoyao Gancaotang group,acupuncture com...