期刊论文

Mitochondrial Dynamics Mediates Myocardial Energy Metabolism in Coronary Heart Disease due to Blood Stasis

Jian, W.-X.

中文

中国实验方剂学杂志

1005-9903

2021

27

21

80-90

10.13422/j.cnki.syfjx.20212197

国家自然科学基金项目（81973753）； 湖南省自然科学基金项目（2018JJ2291）； 研究生质量工程项目（2018CX28,2020CX57）；

本校为第一机构

目的:以冠心病血瘀证形成过程中3个阶段大鼠模型为切入点,从线粒体融合-分裂动态变化的角度探索冠心病血瘀证形成过程能量变化的机制。方法:30只大鼠随机分为空白组6只和模型组24只。空白组给予普通饲料喂养,模型组大鼠高脂饲料适应性喂养7 d后进行维生素D(3 VitD3,30万U·kg~(-1))灌胃,14 d后再予以VitD3灌胃(20万U·kg~(-1)),继续高脂饲料喂养21 d后,随机选择6只大鼠为血瘀证前期组,进行模型验证并同时取材;其余大鼠继续高脂饲养30 d后随机选择6只为亚血瘀证期组;剩下的大鼠为心血瘀阻证期组,继续高脂饲养的同时予以皮下多点注射异丙肾上腺素(ISO,5 mg·kg~(-1))连续3 d, 1周后记录心电图。采...

Objective：To explore the mechanism of energy changes in the three stages of the formation of coronary heart disease due to blood stasis in rat model from the perspective of mitochondrial fusion-fission dynamic changes. Method：Thirty healthy male rats were divided into the blank control group（n=6）and model group（n=24）using SPSS 21.0 simple random sampling method. The rats in the blank control group were fed an ordinary diet，while those in the model group a high-fat diet. After seven days of adaptive feeding，the rats were treated with int...