期刊论文

中文

中国实验方剂学杂志

1005-9903

2023

29

16

134-143

10.13422/j.cnki.syfjx.20230539

本校为第一机构

目的：采用高糖高脂饲料喂养联合腹腔注射链尿佐菌素（STZ）及手术制备全层皮肤缺损的方法制备糖尿病大鼠创面模型，观察肉桂醛对糖尿病大鼠创面愈合情况的影响，并基于PTEN诱导假定激酶（PINK）1/帕金森病蛋白（Parkin）信号通路介导的线粒体自噬探讨肉桂醛对糖尿病大鼠创面的治疗机制。方法：48只雄性SD大鼠随机分为空白组12只，糖尿病组36只，糖尿病组随机分为模型组、肉桂醛组和贝复新组，每组12只，空白组与模型组创面常规消毒后予生理盐水，肉桂醛组创面局部外敷含4μmol·L-1肉桂醛的聚乙二醇400（PEG 400）凝胶，贝复新组创面外敷贝复新凝胶，每日换药1次。观察各组创面愈合率，取干预后...

Objective： To establish a rat model of diabetic wound by feeding on a high-fat and high-sugar diet combined with intraperitoneal injection of streptozotocin（STZ）and surgical preparation of full-thickness skin defects，observe the effect of cinnamaldehyde on the wound healing of diabetes rats，and explore the therapeutic mechanism of cinnamaldehyde in improving wound healing of diabetes rats based on the PTEN-induced putative kinase（PINK1）/Parkin pathway-mediated mitochondrial autophagy. Method： Forty-eight male SD rats were randomly divid...