Ginsenoside Rg1-modified PHBV fibrous scaffold reduces interleukin-1 beta-induced dedifferentiation of articular chondrocytes

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成果类型：

期刊论文

作者：

Li, Yongsheng;Zhong, Risheng;Zhou, Zheng;Liu, Hairong*;Dai, Yao;...

通讯作者：

Liu, Hairong

作者机构：

[Li, Yongsheng; Zhong, Risheng; Liu, Hairong; Dai, Yao] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China

[Zhou, Zheng] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China

[Liu, Hairong] Hunan Univ, Hunan Prov Key Lab Spray Deposit Technol & Applic, Changsha 410082, Hunan, Peoples R China

[Hu, Yibing] Hunan Acad Chinese Med, Changsha 410013, Hunan, Peoples R China

通讯机构：

[Liu, Hairong] H

Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China. Hunan Univ, Hunan Prov Key Lab Spray Deposit Technol & Applic, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

biomaterials;cartilage tissue engineering;functionalization of polymers;ginsenoside Rg1;PHBV fibrous scaffold

期刊：

Journal of Applied Polymer Science

ISSN：

0021-8995

年：

2020

卷：

137

期：

页码：

48378-

DOI：

10.1002/app.48378

基金类别：

National Key Research and Development Program of China [2018YFC1105800]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ2023]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-0170]; Innovation Base of Hunan Province for Postgraduates (2014-2017)

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本校为其他机构

摘要：

Inflammatory environment in the end-stage osteoarthritis (OA) cartilage defects greatly limits the effectiveness of engineered cartilage. It is critical that developing scaffolds intend to be applied in cartilage tissue engineering (CTE) under this pathological condition. In this study, poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) fibrous scaffolds modified by ginsenoside Rg1 could be able to alleviate the dedifferentiation of articular chondrocytes caused by interleukin-1 beta (IL-1 beta), a key inflammatory factor in the pathogenesis of OA. Followed by 5-day incubation with cu...

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Ginsenoside Rg1-modified PHBV fibrous scaffold reduces interleukin-1 beta-induced dedifferentiation of articular chondrocytes

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