Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway

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成果类型：

期刊论文

作者：

Nie, Yusong;Fu, Chengxiao;Zhang, Huimin;Zhang, Min;Xie, Hui;...

通讯作者：

Yan, M;Fan, XR

作者机构：

[Nie, Yusong; Zhang, Huimin; Yan, Miao; Li, Yao; Tong, Xiaopei; Yan, M] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

[Fan, XR; Nie, Yusong; Fan, Xinrong; Xie, Hui; Zhang, Min] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Nie, Yusong] Xianyang Cent Hosp, Xianyang 712000, Shaanxi, Peoples R China.

[Fu, Chengxiao] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Hunan, Peoples R China.

[Fan, Xinrong; Zhang, Min] Shaanxi Univ Chinese Med, Clin Med Coll 1, Xianyang 712000, Shaanxi, Peoples R China.

通讯机构：

[Fan, XR ] H

[Yan, M ] C

Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Celastrol;Diabetic nephropathy;PI3K;AKT;Podocytes;Autophagy;Glomeruli basement membrane

期刊：

BMC Complementary Medicine and Therapies

ISSN：

2662-7671

年：

2020

卷：

期：

页码：

1-14

DOI：

10.1186/s12906-020-03050-y

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81974532, No. 81573686, No. 81903904) and the Fundamental Research Funds for the Central Universities of Central South University (No. 2018zzts926). The funder has no role/influence in this study. Acknowledgements

机构署名：

本校为通讯机构

摘要：

Diabetic nephropathy serves as one of the most regular microvascular complications of diabetes mellitus and is the main factor that causes end-stage renal disease and incident mortality. As the beneficial effect and minute adverse influence of Celastrol on the renal system requires further elucidation, the renoprotective function of Celastrol in early diabetic nephropathy was investigated. In high-fat and high-glucose diet/streptozotocin-induced diabetic rats which is the early diabetic nephropathy model, ALT, AST, 24 h urinary protein, blood ...

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Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway

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