Analysis of active components and molecular mechanism of action of Rubia cordifolia L. in the treatment of nasopharyngeal carcinoma based on network pharmacology and experimental verification

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Ximing;Tao, Yangyang;Xu, Runshi;Luo, Wang;Lin, Ting;...

通讯作者：

He, YC;He, L

作者机构：

[Luo, Wang; Zhou, Fangliang; Tang, Le; Xu, Runshi; Yang, Ximing; Tao, Yangyang; Lin, Ting; He, Yingchun] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

[Lin, Ting; He, Yingchun; He, Lan] Hunan Univ Chinese Med, Hunan Prov Engn & Technol Res Ctr Prevent & Treatm, Changsha 410208, Peoples R China.

[Zhou, Fangliang; Tang, Le; He, Yingchun] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Peoples R China.

[He, Lan] Hunan Univ Chinese Med, Hosp 1, Changsha 410208, Peoples R China.

[He, Yingchun] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

通讯机构：

[He, YC ; He, L ]

Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Hosp 1, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Network pharmacology;Molecular docking;Bioinformatics;Rubia cordifolia L.;Nasopharyngeal carcinoma;Molecular mechanism

期刊：

Heliyon

ISSN：

2405-8440

年：

2023

卷：

期：

页码：

e17078

DOI：

10.1016/j.heliyon.2023.e17078

基金类别：

National Natural Science Foundation of China [82104941, 81874408]; Hunan Provincial Department of Education [21B0359]; Natural Science Foundation of Hunan Province [2022JJ30447, 2023JJ30449, 2023JJ40500]; Natural Science Foundation of Changsha city [kq2208206]; Project of Hunan Provincial Health Commission [S202210541143]; College Student Innovation Project of Hunan Province [22JBZ011]; Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine [2022XJJJ014]; Project of Hunan University of Chinese Medicine [22YS001]; Chinese Academy of Engineering Academician Liang Liu's Workstation of Hunan University of Chinese Medicine; [202207015049]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

The aim of this study is to explore the active components and potential molecular mechanism of action of Rubia cordifolia L. against nasopharyngeal carcinoma (NPC). We used network pharmacology, molecular docking, and bioinformatics analysis to identify the active components and their role against NPC. The experimental verification was detected by MTT, AnnexinV-FITC/PI double fluorescence staining and Western blotting method. Network pharmacology identified that mollugin is one of the most effective components inRubia cordifolia L. Important NPC targets included HSP90AA1, CDK1, EGFR, PIK3CA, M...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Analysis of active components and molecular mechanism of action of Rubia cordifolia L. in the treatment of nasopharyngeal carcinoma based on network pharmacology and experimental verification

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问