Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yan, Lijing;Xu, Xia;He, Zhenyu;Wang, Sheng;Zhao, Linlin;...

通讯作者：

Qiu, Xinjian;Huang, Huiyong

作者机构：

[Qiu, Xinjian; Xu, Xia; Yan, Lijing; Wang, Dongsheng] Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.

[He, Zhenyu] Taizhou Hosp Integrated Tradit Chinese & Western, Taizhou 317500, Zhejiang, Peoples R China.

[Wang, Sheng] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Zhejiang, Peoples R China.

[Zhao, Linlin] Cent South Univ, Dept Hlth Management, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

[Qiu, Juan] Cent South Univ, Dept Nucl Med, Xiangya Hosp 4, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Qiu, Xinjian] C

[Huang, Huiyong] H

Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.

Hunan Univ Tradit Chinese Med, Inst Tradit Chinese Med Diag, Changsha 410208, Hunan, Peoples R China.

语种：

英文

期刊：

BioMed Research International

ISSN：

2314-6133

年：

2020

卷：

2020

DOI：

10.1155/2020/2794263

基金类别：

Youth Foundation of National Natural Science Foundation of China [81202807, 81703963]; Foundation of National Natural Science Foundation of Hunan [2018JJ2667]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M572254]; Scientific Research Project of Chinese Traditional Medicine Administration Bureau in Hunan Province [201806]; Prominent Traditional Chinese Medicine Doctor Suiyu Hu's Inheritance Studio

机构署名：

本校为通讯机构

院系归属：

中医学院

摘要：

Background. Fluoxetine (FLU) is the first-line and widely used medication for depression; however, FLU treatment is almost ineffective in 30%-40% of patients with depression. In addition, there are some problems in FLU treatment, such as delayed efficacy, large side effects, and poor tolerance. Chaihu Shugan San (CSS) is a classic and effective antidepressant Chinese herbal medicine that has been used in China for thousands of years. CSS or coadministration of CSS and FLU has become one of the most recommended methods in the treatment of depres...

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Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex

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