The MRVI1-AS1/ATF3 signaling loop sensitizes nasopharyngeal cancer cells to paclitaxel by regulating the Hippo-TAZ pathway

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成果类型：

期刊论文

作者：

Zhu, Yuxing;He, Dong;Bo, Hao;Liu, Zexian;Xiao, Mengqing;...

通讯作者：

Cao, K

作者机构：

[Xiang, Liang; Cao, K; Zhu, Yuxing; Cao, Ke; Ma, Yanni; Xiao, Mengqing; Gong, Lian] Cent S Univ, Dept Oncol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

[He, Dong] Hunan Univ Chinese Med, Dept Respirat, Peoples Hosp Hunan Prov 2, Changsha 410000, Hunan, Peoples R China.

[Bo, Hao] Cent S Univ, Inst Reprod & Stem Cell Engn, Changsha 410083, Hunan, Peoples R China.

[Liu, Zexian] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China.

[Zhou, Jianda; Liu, Yan] Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Cao, K ] C

Cent S Univ, Dept Oncol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

语种：

英文

期刊：

Oncogene

ISSN：

0950-9232

年：

2019

卷：

期：

页码：

6065-6081

DOI：

10.1038/s41388-019-0858-7

基金类别：

Funding This work was supported by the National Natural Science Foundation of China (81874137), the Outstanding Youth Foundation of Hunan Province (2018JJ1047), the Huxiang Young Talent Project (2016RS3022), the Innovation-Driven Project of Central South University (2017CX012), the Fundamental Research Funds for the Central Universities of Central South University, Grant/Award Number: 2018zzts955, and the New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University (20150201, JY201710).

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摘要：

Long non-coding RNA (lncRNA) plays an important role in malignant tumor occurrence, development, and chemoresistance, but the mechanism of how they affect nasopharyngeal cancer (NPC) paclitaxel chemosensitivity is unclear. In this study, lncRNA array of CNE-1 and HNE-2 paclitaxel-resistant cells and their parental strains revealed that the paclitaxel-resistant strains had significantly lower MRVI1-AS1 (murine retrovirus integration site 1 homolog antisense RNA 1) expression than the parental strains, and that MRVI1-AS1 overexpression in vitro a...

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The MRVI1-AS1/ATF3 signaling loop sensitizes nasopharyngeal cancer cells to paclitaxel by regulating the Hippo-TAZ pathway

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