期刊论文

中文

中国中医药科技

1005-7072

2004

11

4

208-209

10.3969/j.issn.1005-7072.2004.04.007

湖南省科技厅重点项目No .0 3ssy10 0 3 -3； 湖南省卫生厅课题No .2 0 0 2 0 0 6；

本校为第一机构

目的:探讨消心痛胶囊对大鼠缺血性心肌损伤的保护作用.方法:采用大剂量异丙肾上腺素皮下注射,造成大鼠缺血性心肌损伤模型,检测各组大鼠血中肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)的含量,并取心脏行心肌病理切片.结果:消心痛胶囊中、高剂量组CK、CK-MB、LDH含量明显低于模型组(P＜0.01),与阳性对照组(地奥心血康)比较无明显差异(P＞0.05);心肌病理切片结果显示,模型组心肌灶性坏死严重,而给药组多数心肌纤维染色均匀,无出血及坏死.结论:消心痛胶囊能有效地预防大鼠缺血性心肌损伤.

Objective:To approach the protective effects of xiaoxintong capsule on acute myocardial injury.Method:The rat model of acute myocardial injury was established by high-dose isoprenaline subcutaneous injection.Then the contents of CK?CK-MB and LDH in blood of rats were tested and heart was taken into myocardium pieces. Results: The contents of CK?CK-MB and LDH was obviously lower in high-dose group and middle-dose group of xiaoxintong capsule than that in the model group.There was no distinct difference between xiaoxintong capsule and di'aoxinxuekang.(P>0 05);the slice of myocardium showed that ...