PPM1D is a prognostic marker and therapeutic target in colorectal cancer

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成果类型：

期刊论文

作者：

Peng, Tian-Shu;He, Yong-Heng*;Nie, Tian;Hu, Xiang-Dang;Lu, Hai-Yan;...

通讯作者：

He, Yong-Heng

作者机构：

[Luo, Min; He, Yong-Heng; Hu, Xiang-Dang; Peng, Tian-Shu; Lu, Hai-Yan] Hunan Univ Chinese Med, Dept Anorectal Dis, Affiliated Hosp 2, Changsha 410005, Hunan, Peoples R China.

[Yi, Jian; Nie, Tian; Shuai, Yun-Fei] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Blood & Oncol, Changsha 410007, Hunan, Peoples R China.

[He, Yong-Heng] Hunan Univ Chinese Med, Dept Anorectal Dis, Affiliated Hosp 2, 233 Caie North Rd, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[He, Yong-Heng] H

Hunan Univ Chinese Med, Dept Anorectal Dis, Affiliated Hosp 2, 233 Caie North Rd, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

PPM1D;biomarker;colorectal cancer;prognosis

期刊：

Experimental and Therapeutic Medicine

ISSN：

1792-0981

年：

2014

卷：

期：

页码：

430-434

DOI：

10.3892/etm.2014.1762

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

第二中医临床医学院

摘要：

Protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) has been associated with carcinogenesis. The present study investigated PPM1D expression as a potential biomarker in colorectal cancer (CRC). PPM1D expression was assessed using immunohistochemistry in 368 patients with CRC. The correlation between PPM1D expression, clinicopathological features and prognosis was analyzed. PPM1D small interfering (si)RNA-induced PPM1D silencing was performed in CRC cell lines to assess the effect of PPM1D on tumor cell proliferation and invasion in vitro. A total of 68.48% (252/368) of the CRC samples display...

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PPM1D is a prognostic marker and therapeutic target in colorectal cancer

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